Protein Details: Glutamate receptor ionotropic; NMDA 1

Protein ID

ICDB_Pro_0495

Protein Name

Glutamate receptor ionotropic; NMDA 1

Gene Name

Grin1; Nmdar1

Organism

Rattus norvegicus (Rat)

Length

938 amino acids

AlphaFoldDB

AF-P35439-F1-model_v4.pdb

Function

Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.

Sequence

MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516..518; /ligand="glycine"; BINDING 523; /ligand="glycine"; BINDING 688; /ligand="glycine"; BINDING 732; /ligand="glycine"

Disease

Location

Detected throughout the brain; in brain cortex; cerebellum; thalamus and olfactory bulb

DOI ID

10.1038/354031a0; 10.1016/0014-5793(92)80648-z; 10.1073/pnas.89.18.8552; 10.1016/0896-6273(93)90209-a; 10.1016/0005-2736(93)90249-y; 10.1016/0006-291x(92)91701-q; 10.1126/science.256.5060.1217; 10.1016/s0021-9258(18)53849-7; 10.1523/jneurosci.21-20-07985.2001; 10.1523/jneurosci.21-04-01228.2001; 10.1124/mol.62.5.1119; 10.1152/jn.00531.2001; 10.1016/j.neuron.2004.08.003; 10.1016/j.neuint.2005.04.011; 10.1523/jneurosci.3799-05.2006; 10.1016/j.neuron.2006.04.005; 10.1016/j.jmb.2007.11.105; 10.1097/wnr.0b013e328317f05f; 10.1038/ncomms1871; 10.1021/pr400783j; 10.15252/embj.201593070; 10.1124/mol.115.103036; 10.1016/j.neuron.2017.03.018; 10.1093/emboj/cdg303; 10.1038/nature04089; 10.1016/j.neuron.2005.05.022; 10.1523/jneurosci.6041-10.2011; 10.1126/science.1251915; 10.1038/nature17679; 10.1016/j.neuron.2016.08.014; 10.1124/mol.116.107912

RefSeq

NP_001257531.1 [P35439-2]; NP_001257532.1 [P35439-6]; NP_001257534.1 [P35439-3]; NP_001257537.1 [P35439-7]; NP_001257539.1 [P35439-5]; NP_001274352.1 [P35439-4]; NP_058706.1 [P35439-1]